Category: Publication

IVRI faculty Prof. Greg Barton recently demonstrated the importance of the location of Toll-like-receptors (TLRs). In a new study published in PNAS, Alison Stanbery, Zachary Newman, and Prof. Gregory Barton show that not only location of TLR-9 is primordial, but dysregulated activation of TLR-9 at different stages of life, induced specific inflammatory response. This work helps us understand unique aspects of TLR9-driven inflammatory disease, and has relevance for studying and developing new therapeutic avenues for both infectious and autoimmune diseases.